Assistant Professor of Neurosurgery
Dr. Pawel Kudela specializes in biological signal data modeling and analysis. His research focuses on realistic and detailed modeling of cortical dynamics (cortical electrical stimulation, auditory processing, seizures) to understand experimental observations from novel microelectrode recordings of epilepsy patients.
current projects:
Computational Modeling of Subdural Cortical Stimulation: This project focuses on investigation of the effect of subdural cortical electrical stimulation. In these studies, high-resolution cortical network models are used to quantify the effect of direct electrical stimulation of cortical surface by an electrode of realistic size.
Microstimulation Patterns to Elicit Biomimetic Sensory Feedback: The goal of this project is to use computational modeling techniques to improve somatosensory feedback in BCI through biomimetic intracortical microstimulation. Simulated extracellular signals from a high-resolution computational model of S1 are fitted to single-unit activity recordings in humans in response to ICMS.
Hearing in Background Noise: The Role of Cortical Adaptation: Listening difficulties in background noise are common in individuals with hearing loss and affect up 10% of normal-hearing individuals. This project combines intracranial recordings from normal and impaired listeners with a multiscale neuronal model of auditory cortex to investigate the relationship between cortical adaptation and listening ability.
selected papers
- Kudela P, Boatman-Reich D, Beeman D and Anderson WS (2018) Modeling Neural Adaptation in Auditory Cortex. Front. Neural Circuits 12:72. doi: 10.3389/fncir.2018.00072
- Kudela P and Anderson WS (2015) Computational Modeling of Subdural Cortical Stimulation: A Quantitative Spatiotemporal Analysis of Action Potential Initiation in a High‐Density Multicompartment Model. Neuromodulation 18: 7. doi: 10.1111/ner.12327
- Kudela P, Bergey GK and Franaszczuk P (2009) Calcium involvement in regulation of neuronal bursting in disinhibited neuronal networks: insights from calcium studies in a spherical cell model. Biophys J 97:12. doi: 10.1016/j.bpj.2009.09.027
- Kudela, P, Franaszczuk, P and Bergey, G (2003) Changing excitation and inhibition in simulated neural networks: effects on induced bursting behavior. Biol. Cybern. 88:276. doi: 10.1007/s00422-002-0381-7